An ancient Indian spice turmeric
again in the spotlight. A new study found that an extract of turmeric can selectively and safely kill the cancer stem cells that can't do chemo and radiotherapy.
Sensational new study published in the journal Anticancer Research shows that one of the most studied and promising natural ingredients for the treatment of cancer – the polyphenols of the ancient spice turmeric
, also known as curcumin
– has the ability to selectively kill cancer stem cells, which are the basis of cancer malignancy. At the same time, it is absolutely not toxic to normal stem cells necessary for tissue regeneration.
Scientific paper entitled “Curcumin and Cancer Stem Cells: Curcumin has an asymmetric effect on cancer and normal stem cells”
, describes a wide variety of molecular mechanisms identified to date by which curcumin attacks cancer stem cells (RGC).
RAC are a small subpopulation simulatenously cells amongst cancer cells of the tumor. They produce all the other more differentiated cancer cells of the tumor, making them the most lethal carcinogenic cells among all cancer cells. I believe that these RSK tolerate chemotherapy, radiation therapy, and can be triggered to be more invasive due to the surgical intervention. They are responsible for a more aggressive return of the disease after treatment or complete failure of treatment.The study identified the following 8 molecular mechanisms by which curcumin acts and kills cancer stem cells:
1. Reduces the effects of interleukin-6 (IL-6)
2. Reduces the effect of interleukin-8 (IL-8)
3. Reduces the effects of interleukin-1 (IL-1)
4. Blocking and binding of cytokines CXCR1 and CXCR2
5. Modulation of Wnt signaling pathway
6. Modulation of Notch road
7. Modulation of Hedgehog way
8. Way modulation of FAK/AKT/FOXo3a
As you can see, with these 8 examples, curcumin shows a very deep level of complexity in simultaneously modulating molecular pathways. Common cytotoxic chemotherapy is not capable of such delicate and intelligent action, because it potentially applies to any rapidly dividing cells by destroying their DNA in the most vulnerable stage of cell division.
While chemotherapy is not able to discriminate between healthy and cancer cells. Curcumin, in turn, due to its selective cytotoxicity, acts on the most dangerous cells – cancer stem cells, leaving healthy cells untouched.
Curcumin and Normal Stem Cells (NSC)
Normal stem cells necessary for body, as they are responsible for differentiating into normal cells that need to replace damaged or diseased. If curcumin destroy healthy cells like radiation or chemotherapy, he would not have been such a compelling alternative to these treatments. The study also dealt with this issue.
The safety of curcumin has been established a long time ago, as it is used as a cooking spice for thousands of years. The question is: why curcumin does not have the same destructive effect on normal stem cells (NSC), he works at the RSC.
There are several possible reasons why a curcumin has a toxic effect on RGC, without affecting NSC:
1. Cancer cells absorb much more curcumin than normal cells.
2. Curcumin changes the microenvironment of cells so that it deteriorates to Cancer Stem Cells (RGC) and improved for Normal Stem Cells (NSC).
3. Curcumin not only directly attacks the RSC, but also stimulates their differentiation in less malignization, more benign cells.
This study complements the growing support for the idea that safe, time-tested, natural substances are far superior to synthetic
. Given the evidence that safe and effective alternatives may already exist, to justify the use of chemotherapy, radiotherapy and even surgery becomes more difficult as the only official methods of cancer treatment.
Already collected a lot of facts and there are many studies proving that these treatments actually worsen the prognosis, and in some cases contribute to an increase in the proportion of RAC in the tumor, thereby leading to greater malignancy.
It was found that radiation therapy for breast cancer stimulates the RAC, increasing their malignancy and oncogenicity 30 times. One can hardly call it progress, taking into account the role played by the RAC, especially at relapse after treatment.
Of course turmeric and its components such as curcumin are not approved by governing medical organizations in Western countries (such as the Food and Drug Administration in USA) that dictate the methods of treatment all around the world. And once they are approved, so that these organizations aggressively forbid them to use for treatment. This means that your oncologist is able to offer you in the foreseeable future treatment with curcumin as an alternative to chemotherapy or radiation.
However, this does not mean that curcumin is not working, how can a to think if it is not used oncologists. In fact, turmeric has the effect at 700 various diseases and pathological conditions.
There are more than 1500 scientific papers on the database of the National Library of Medicine's bibliographic database MEDLINE, which is accessed through www.pubmed.gov.
Turmeric so unique that it seems this plant has a mind and charity.
Of course, the point is not to wait until serious health problems when you need to take heroic doses of spices or herbs.
It is important to remember that the ancient cultures have used these spices as turmeric in culinary doses, as part of their ethnic cuisine. These smaller amounts were used for preventive purposes, which eliminates the need to continue to use large doses of the disease.published
The text is written according to the article “Turmeric''s ‘Smart Kill’ Properties Put Chemo & Radiation To Shame”
Author: Sayer JI
The materials are for informational purposes. Remember, self-life-threatening, for advice regarding the use of any medicines and methods of treatment, contact your doctor.
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