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As a "reprogram" the cancer
Welcome to our readers in the pages of the blog iCover . The theme of our publication will become one of the most acute problems of humanity - oncology, or rather - a fundamentally new approach in the fight against the insidious disease, proposed by a group of medical researchers from the Mayo Clinic (Mayo Clinic, Florida).
Research conducted by a team of medical researchers from the Mayo Clinic it possible to develop a new concept in the fight against cancer, according to which cancer cells can be "reprogrammed" by returning them to the original healthy state. According to the concept proposed by the experts, "administration" in the affected cell-specific "biological code" will initially "abort", and for the reverse process and expand the development of cancer.
The method of reprogramming of malignant cells based on the results of studies t. N. "Binding" proteins that act as a kind of glue, binding together the same type of cells and at the same time interacting with the key element in the production of organic molecules - microRNAs (hereinafter miRNAs).
Protein miRNAs acts as an organizer of large-scale intracellular "productive" programs derives baseline information from different groups of genes. During the experiments, the scientists found out that healthy cells contact with each other is accompanied by suppression of genes responsible for growth and division by miRNAs. Due to the low concentration of miRNAs in cancer cells, the regulatory function of suppressing virtually ensured or not working properly. Thus, cancer cells deprived of any deterrent divide and grow uncontrollably.
Scientists idea is that the return of cancer cells to live according to the laws of healthy cells is sufficient to increase the protein concentration miRNAs to normal levels. The results of laboratory tests conducted by scientists with the cells of malignant tumors of the breast and bladder successful.
"Our research has combined two areas: the aggregation (association) cells and miRNA-biology that were previously considered independent. This approach allowed to reveal the true cause of the problem, hiding from the scientists for a very long time. And, what is most important - that is what our discovery provides the hands of a new and effective method of dealing with cancer ... "- says a leading expert scientific group Antonis Koertidis (Antonis Kourtidis).
"Restoring levels of miRNA in cancer cells to their normal values - it is nothing like the restoration of cellular" brake, "which, in turn, allows you to restore the normal functioning of these cells ... The experiments were conducted on cells of some of the most aggressive forms of malignant tumors were given more than promising results, "- says Koertidis.
However, it was found that a residual amount of mutated proteins - p120 uncontrolled growth stimulants and E-cadherin in cells after balancing the miRNA level is still observed. "Therefore, we studied protein-protein under the name PLEKHA7, responsible for the normal functioning and healthy cells, affecting the miRNAs and limiting the production of E-cadherin and p120».
It was concluded that: the role of regulator of level of microRNAs, P120 and E-cadherin in the cell performs the biological microprocessor PLEKHA7, malfunctions that lead to unbalance the whole regulatory system of the cell. In this case, the key genetic instructions are isolated cells, which leads to the formation of a malignant tumor.
Scientists believe that the cause of universal and does not depend on the form of developing pathology.
"We examined a large number of samples of different kinds of tumors and everywhere they lack a workable PLEKHA7-mechanism" - the researchers write. - "It's like a speeding uncontrollably car that gas is squeezed until it stops (protein p120), and there are no brakes (complex PLEKHA7-microprocessor). Now we can slow down the uncontrolled movement, and soon we will be able to finalize the full and effective method to disperse a safe stop of the "cell car" and return it to the "normal way» ».
Thus, the cancer cells to kill in any existing alternative therapies in the above method, after the correction of the system at all levels in neutral (innocuous condition). This will achieve results much faster, and most importantly, with minimal impact on the patient's health.
The picture from the magazine Daily Mail, showing the result of the use of technology "reprogram" cells. Cells in the figure returned to a benign condition. Published in Daily Mail i>
According to another member of the team - Panos Anastasiadis (Panos Z. Anastasiadis) approach proposed by the group and described in the journal Nature Cell Biology is universal and can be used to treat most cancers except for blood cancer and brain.
Some scientists have taken the side of the skeptics point out the difference between the experiments conducted in the laboratory and actual treatment of cancer patients. Not discounting the results of experiments, they still believe that even in the event of a significant improvement of the patients in the final stages of chemotherapy can not be avoided. However, skeptics and experts, who saw in the method of a real breakthrough in the treatment of cancer in solidarity of the opinion: Experiments need to continue and maintain the highest level.
Dear readers, we are ready to please you with their publications and will do everything possible to ensure that the time spent with us will bring pleasure to you. And, of course, do not forget to subscribe to our heading and promise - will not be bored!
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Source: geektimes.ru/company/icover/blog/263308/
Research conducted by a team of medical researchers from the Mayo Clinic it possible to develop a new concept in the fight against cancer, according to which cancer cells can be "reprogrammed" by returning them to the original healthy state. According to the concept proposed by the experts, "administration" in the affected cell-specific "biological code" will initially "abort", and for the reverse process and expand the development of cancer.
The method of reprogramming of malignant cells based on the results of studies t. N. "Binding" proteins that act as a kind of glue, binding together the same type of cells and at the same time interacting with the key element in the production of organic molecules - microRNAs (hereinafter miRNAs).
Protein miRNAs acts as an organizer of large-scale intracellular "productive" programs derives baseline information from different groups of genes. During the experiments, the scientists found out that healthy cells contact with each other is accompanied by suppression of genes responsible for growth and division by miRNAs. Due to the low concentration of miRNAs in cancer cells, the regulatory function of suppressing virtually ensured or not working properly. Thus, cancer cells deprived of any deterrent divide and grow uncontrollably.
Scientists idea is that the return of cancer cells to live according to the laws of healthy cells is sufficient to increase the protein concentration miRNAs to normal levels. The results of laboratory tests conducted by scientists with the cells of malignant tumors of the breast and bladder successful.
"Our research has combined two areas: the aggregation (association) cells and miRNA-biology that were previously considered independent. This approach allowed to reveal the true cause of the problem, hiding from the scientists for a very long time. And, what is most important - that is what our discovery provides the hands of a new and effective method of dealing with cancer ... "- says a leading expert scientific group Antonis Koertidis (Antonis Kourtidis).
"Restoring levels of miRNA in cancer cells to their normal values - it is nothing like the restoration of cellular" brake, "which, in turn, allows you to restore the normal functioning of these cells ... The experiments were conducted on cells of some of the most aggressive forms of malignant tumors were given more than promising results, "- says Koertidis.
However, it was found that a residual amount of mutated proteins - p120 uncontrolled growth stimulants and E-cadherin in cells after balancing the miRNA level is still observed. "Therefore, we studied protein-protein under the name PLEKHA7, responsible for the normal functioning and healthy cells, affecting the miRNAs and limiting the production of E-cadherin and p120».
It was concluded that: the role of regulator of level of microRNAs, P120 and E-cadherin in the cell performs the biological microprocessor PLEKHA7, malfunctions that lead to unbalance the whole regulatory system of the cell. In this case, the key genetic instructions are isolated cells, which leads to the formation of a malignant tumor.
Scientists believe that the cause of universal and does not depend on the form of developing pathology.
"We examined a large number of samples of different kinds of tumors and everywhere they lack a workable PLEKHA7-mechanism" - the researchers write. - "It's like a speeding uncontrollably car that gas is squeezed until it stops (protein p120), and there are no brakes (complex PLEKHA7-microprocessor). Now we can slow down the uncontrolled movement, and soon we will be able to finalize the full and effective method to disperse a safe stop of the "cell car" and return it to the "normal way» ».
Thus, the cancer cells to kill in any existing alternative therapies in the above method, after the correction of the system at all levels in neutral (innocuous condition). This will achieve results much faster, and most importantly, with minimal impact on the patient's health.
The picture from the magazine Daily Mail, showing the result of the use of technology "reprogram" cells. Cells in the figure returned to a benign condition. Published in Daily Mail i>
According to another member of the team - Panos Anastasiadis (Panos Z. Anastasiadis) approach proposed by the group and described in the journal Nature Cell Biology is universal and can be used to treat most cancers except for blood cancer and brain.
Some scientists have taken the side of the skeptics point out the difference between the experiments conducted in the laboratory and actual treatment of cancer patients. Not discounting the results of experiments, they still believe that even in the event of a significant improvement of the patients in the final stages of chemotherapy can not be avoided. However, skeptics and experts, who saw in the method of a real breakthrough in the treatment of cancer in solidarity of the opinion: Experiments need to continue and maintain the highest level.
Dear readers, we are ready to please you with their publications and will do everything possible to ensure that the time spent with us will bring pleasure to you. And, of course, do not forget to subscribe to our heading and promise - will not be bored!
Our other articles:
Наушники for the city streets. Music as lifestyle How to extend battery life work laptop Правильный blender is your best assistant in the kitchen Инфографика: how to select the HDD for computer and laptop As choose a graphics tablet for drawing
Source: geektimes.ru/company/icover/blog/263308/
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