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Exercise is useful for chemotherapy
Scientists at the University of Pennsylvania found that exercise can provide an additional benefit for patients undergoing chemotherapy.
Their experiments on mice showed that by combining exercise with chemotherapy, the tumor shrank more than just from the course of treatment. Joseph Libonati’s group decided to test how exercise protects against the negative side effects associated with doxorubicin.
Previous studies have shown that physical activity before receiving chemotherapy can protect heart cells from the toxic effects of doxorubicin, but few have looked at the effects of exercise during the course.
Two groups of mice infected with melanoma received either the drug or a placebo. One of each pair of rodents had exercise, walking for 45 minutes five days a week, treadmills, and the rest of the mice were sedentary.
The scientists examined the hearts of the animals using an echocardiogram and tissue analysis. As expected, doxorubicin led to decreased heart function and increased tissue fibrosis. But most importantly, mice that received chemotherapy and exercise had significantly smaller tumors after two weeks than mice that received the drug alone.
Further research will examine exactly how physical activity enhances the effect of the drug, but the researchers suggest this may be partly because blood flow to the tumor increases, resulting in more drugs.
Libonati: “If exercise helps, you could use a smaller dose of the drug and get fewer side effects.”
Source: nauka24news.ru/
Their experiments on mice showed that by combining exercise with chemotherapy, the tumor shrank more than just from the course of treatment. Joseph Libonati’s group decided to test how exercise protects against the negative side effects associated with doxorubicin.
Previous studies have shown that physical activity before receiving chemotherapy can protect heart cells from the toxic effects of doxorubicin, but few have looked at the effects of exercise during the course.
Two groups of mice infected with melanoma received either the drug or a placebo. One of each pair of rodents had exercise, walking for 45 minutes five days a week, treadmills, and the rest of the mice were sedentary.
The scientists examined the hearts of the animals using an echocardiogram and tissue analysis. As expected, doxorubicin led to decreased heart function and increased tissue fibrosis. But most importantly, mice that received chemotherapy and exercise had significantly smaller tumors after two weeks than mice that received the drug alone.
Further research will examine exactly how physical activity enhances the effect of the drug, but the researchers suggest this may be partly because blood flow to the tumor increases, resulting in more drugs.
Libonati: “If exercise helps, you could use a smaller dose of the drug and get fewer side effects.”
Source: nauka24news.ru/
