I think you know that if a car's engine runs on diesel fuel, it has more power and mileage and more economical. But if you run this fuel in your Corvette, the car will not go, though the engine sounds fine...
Fat people with insulin resistance or, as we now call this condition "metabolic syndrome" — a sort of "diesels". In the process of evolution they are favorable for the survival of the type of metabolism that allows them to quickly and effectively learn a meager diet, it is easier to endure hunger and to survive on long journeys.
This property was fixed genetically, and the gene became dominant, making the offspring of insulin-resistant. It is beneficial for evolution, because gene provides low energy demands of the body when fasting, more efficient storage and less waste fat. He was allowed in ancient times, has its pregnant women to bear fruit in the long hungry winter, increased reproductive period of life and contributed to the birth of larger and more viable the fetus.
Native full woman personified a healthy mother, able to give life to strong offspring, and a complete man — a wealthy person who eats plenty.
Thus, in humans there are two main types of metabolism: some insulin-resistant genetically, others not
. The first one is more resilient and hardy, but only IF... "pour need fuel".And that's where problems arise.
If starvation in Pakistan to be insulin-resistant — it means to survive in modern America — it means to die. The old saying, "lose weight is fat, skinny will die", is outdated: the skinny live longer.
The Western way of life has made three major changes in the way of human existence:
- high carbohydrate diet
- physical inactivity,
- the reduction of the dream,
that completely rebuilds the waste Nature of the mechanism of regulation of metabolism in the human body.
Once in the abundance of cheap abundant and easily digestible food, "diesel engines" natural purpose continue to accumulate fat. Behind the plow, they do not go, and energy demands on the management of computer mouse is so tiny that do not allow "shake" the accumulated fats. Like all in the West, they generally are moving less and sleeping on average 2 hours less than their grandparents. Currently in America, every second person has an increased weight, one-third are obese.
In the West, the insulin-resistant people constitute the main contingent are entering at epidemic proportions an army of diabetics, since the advantage they converted into a drawback... why pay a more short life (~14 years), more frequent strokes, heart attacks, cataractae, amputations, cancer, and spend 10 times more money on maintaining their health than those who do not have the genetic "advantages". Doctors all with great enthusiasm and in increasing quantities prescribed medicines for lowering sugar, cholesterol, pressure, antidepressants and other "anti", but "things are there", which is tantamount to pouring diesel fuel in a Corvette.
Fortunately, all the negative effects of insulin resistance do not develop in odnochase.
Takes up to 10-25 years to develop diabetes during which the body is louder "screaming" about the issue but can't hear him. Not long ago, insulin resistance was seen only as a risk factor for developing diabetes, what we can not agree. But, as to limit their needs, no one committed entirely relying on the Almighty Western medicine, virtually all insulin-resistant people sooner or later become diabetic, in connection with which is a condition called pre-diabetes or "metabolic syndrome".
It is known that all bodies are different depending on their supply of glucose, which is the energy fuel for the cells. Therefore, they have different receptors (Glut 1-5), which combines with insulin, allow a certain amount of sugar to get inside cells, in accordance with its physiological needs. The most resistant organs are liver, skeletal muscle and b-cells of the pancreas (Glut -2), because they can wait and stand "in line for sugar," getting after it more important for functioning of brain cells and erythrocytes.
One role of insulin is to carry the sweet burden to the cage and "the doorbell". Have insulin-resistant people are initially more efficient transport and higher insulin levels, hence, when overeating "the door won't open" because of the employment of the receptors of the previous delivery, the new goods, and insulin are "dumped" in front of her.Insulin is the only hormone that lowers the sugar level in the blood.
Because ancient humans rarely eat a lot and regularly, and their diet before the invention of bread and sugar contain little carbohydrates, Nature has created a lot of insulin antagonists (epinephrine, growth hormone, thyroid hormone, glucocorticoids, glucagon, ACTH, etc.) that immediately respond to the increase in its quantity, because, by definition, this implies a sharp decline in blood sugar and the danger to life.In metabolic syndrome
, thus, a paradoxical situation resembles a vicious circle — all improved
- Increased adrenaline raises blood pressure and triglycerides in the blood.
- Aldosterone retains sodium and increases the pressure too.
- Steroids contribute to the development of hypertension, insomnia, osteoporosis and inhibit the activation of thyroid hormones.
- Glucagon keeps the sugar at a high level.
And the insulin, is also located in excess, stimulates the growth of body weight and cell division, disrupts lipid and calcium exchange, damages the blood vessels, causing hunger, headache, dizziness, panic attacks, depression. It disrupts the balance of sex hormones, contributing to the development of impotence, polycystic ovaries, uterine fibroids, fibrocystic breast, acne, hirsutism and other various "virtues", referring to the long list of complications, which is, in fact, suffer and die prematurely diabetics and fat men with metabolic syndrome.Thus, the sensitivity of our tissues to insulin, by and large, determines our health and the possibility of developing a variety of diseases, from acne to cancer.
If you fill in your luxury "Corvette" is not the fuel, long you ride it. Because, unfortunately, while genetics cannot be changed, maybe a simple, but reliable "diesel sedan"?
Also interesting: the Hormone insulin: everything You need to know! A terrible symptoms of DIABETES
I repeat that all complications insulin-resistance develops over a period of 15-30 years. You have time to prevent them.
Well, if your Corvette has stalled, switch to another "mode of transport".published
Author: Elena Coles, M. D., doctor of medical Sciences, Professor