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Personalized medicine: DNA treatment
Description: How a genetic passport and gut bacteria become key to health A review of revolutionary methods for 2025: from genome editing to predicting diseases decades before they appear.
Genetic Designer: CRISPR 2.0
A new version of CRISPR-Cas9 with the addition of cytosine improved the accuracy of gene editing by 3,000 times, minimizing ophtharget effects. The technology is already being used to:
- Treatment of hemophilia through correction of blood stem cells
- Creating organ donor pigs with human compatibility genes
- Regeneration of heart tissue after a heart attack
Microbiome as a Diagnostic
Analysis of gut bacteria now predicts risks:
- Alzheimer's disease - 15 years before symptoms
- Type 2 Diabetes by Firmicutes/Bacteroidetes
- Autoimmune diseases – through Akkermansia imbalance
The Anti-Age Revolution: Timekeeping of DNA
The MethylAge epigenetic clock analyzes 353 DNA methylation sites, determining biological age with a margin of error of 1.5 years. Clinics offer:
- Personalized telomerase therapy
- APOE4 gene correction for dementia prevention
- Microbiome cocktails against cellular aging
Case: Patient 0
A 45-year-old man with a genetic predisposition to cancer received:
Parameter TherapyResult for 1 year Gene BRCA1CRISPR-correction Risk reduced from 85% to 2% Microbiome Transplantation Inflammation by 70%EpigeneticsMethylation Diet Bioage reduced by 3.2 years
Ethical coordinates
Personalized medicine faces dilemmas:
- Price: complete genomic analysis + therapy = $12,000
- Privacy: 1 genome = 100 GB of data
- Risks of CRISPR: 0.7% of cases of chromosomal abnormalities
Glossary
Ophtharget effect Non-targeted editing of CRISPR genes
DNA methylation Epigenetic modification that affects gene expression
Fecal transplantation Transferring the donor’s microbiome to the recipient
APOE4 Genetic variant associated with Alzheimer’s disease
