The researchers found a new gene responsible for skin cancer Bashny.Net

Scientists at Stanford University found that a genetic mutation by ultraviolet light is the driving force behind millions of cases of skin cancer.

According to new data, the mutation occurs in the KNSTRN gene, which is involved in cell division. Earlier KNSTRN was not known as the cause of cancer in humans, but studies show that it can be one of the most frequently mutated oncogenes in the world.

Paul Khavari says: "This previously unknown oncogene is activated by sunlight and drives the development of cutaneous carcinoma squamous cell carcinoma. Our study shows that skin cancers arise differently from other cancers and that a single mutation can cause genomic catastrophe."

Khavari and his colleagues made the discovery by investigating the genetic causes of cutaneous squamous cell carcinoma. They compared the DNA sequences of genes in tumor cells from normal skin and looked for mutations that were only in tumors. They find 336 candidate genes for further study, including some well-known culprits. The two most frequently mutated gene CDKN2A and TP53, have been associated with squamous cell carcinoma.

Detection of a third, frequently mutating gene, KNSTRN, was a surprise. Identification of a new oncogene will allow researchers to better understand how these types of skin cancer develop. It can also help to develop new methods of treatment of this disease.

Source: nauka24news.ru/