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Scientists have found a way to "turn off" neuropathic pain
Scientists have found possible way to block neuropathic pain in the brain in animals induced by chemotherapeutic agents, and bone cancer. The opening may have an impact on the elimination of this type of pain in humans.
Нейропатическая pain is the result of pathological excitation of neurons in the nervous system responsible for the normal pain arising as a response to physical impact. Scientists have demonstrated that stimulation of аденозинового A3 receptor in the brain and spinal cord relieves pain without causing habituation, unlike opioids.
pain is a huge problem, as it causes not just in a bad mood, but also the loss of working capacity - respectively, the losses are expressed in monetary terms. The bulk of the modern way to stop the pain has such actions, including the body's addiction to drugs and the need to increase the dose to get the effect. The most successful approaches work with the "paths" in the nervous system: it is a calcium channel blockers, opioid receptors and adrenergic receptors.
Adenosine already had potential as a painkiller for humans, but scientists have little work with this method, as the effects on adenosine receptors can cause a huge amount of side effects. New исследование showed , that A3 receptor activation in the brain and spinal cord of rodents prevents pain from nerve damage - a source of chronic pain.
The experiment was conducted on rats and Sprague Dawley breed mice Salvatore. Animals damaged nerves, causing various types of chronic pain, followed by exposure to treated A3 receptors. Adenosine kinase inhibitor ABT-702 was able to save animals from pain. Now it is small: test the method on human beings.
Source: geektimes.ru/post/242110/
Нейропатическая pain is the result of pathological excitation of neurons in the nervous system responsible for the normal pain arising as a response to physical impact. Scientists have demonstrated that stimulation of аденозинового A3 receptor in the brain and spinal cord relieves pain without causing habituation, unlike opioids.
pain is a huge problem, as it causes not just in a bad mood, but also the loss of working capacity - respectively, the losses are expressed in monetary terms. The bulk of the modern way to stop the pain has such actions, including the body's addiction to drugs and the need to increase the dose to get the effect. The most successful approaches work with the "paths" in the nervous system: it is a calcium channel blockers, opioid receptors and adrenergic receptors.
Adenosine already had potential as a painkiller for humans, but scientists have little work with this method, as the effects on adenosine receptors can cause a huge amount of side effects. New исследование showed , that A3 receptor activation in the brain and spinal cord of rodents prevents pain from nerve damage - a source of chronic pain.
The experiment was conducted on rats and Sprague Dawley breed mice Salvatore. Animals damaged nerves, causing various types of chronic pain, followed by exposure to treated A3 receptors. Adenosine kinase inhibitor ABT-702 was able to save animals from pain. Now it is small: test the method on human beings.
Source: geektimes.ru/post/242110/
