Moles — an indicator of the predisposition of women to breast cancer

Almost simultaneously published two new studies on the link between moles and breast cancer.Two teams of scientists from the USA and France claim that the nevi in other words, moles can be an indicator of predisposition of women to the risk of developing breast cancer.


Moles represent benign skin tumors that occur most often in fair-skinned than dark-skinned people, and may be congenital or appear later. Studies of twins have shown that the appearance of moles by 40-80% due to genetic influence.


Earlier studies showed that women with lots of moles are at a greater risk of hormonal diseases such as endometriosis, leiomyoma and thyroid disease.


Nevi can also be a marker of predraspolozhennosti to melanoma and this phenomenon is associated with the gene CDKN2A. Inactivation of this gene, which is involved in cell cycle regulation, associated, alas, with breast cancer.


Scientists from the French National Institute of Health and Medical Research (Institut National de la Santé et de la Recherche Médicale (INSERM)) went further and checked whether the number of moles with the risk of breast cancer.


To do this, they analyzed data from the monitoring of breast cancer, which were conducted for 89 902 women for 18 years. Women in particular, are asked to report whether they had or not moles and how many.


The report showed that women with "very many" nevi, the risk of developing breast cancer was 13% higher than that of women, whose skin was clean. But when the data was correlated with known risk factors of breast cancer (presence of benign tumors, family history of cancer, etc.), results of the research ceased to be statistically correct.


In their study, the authors write that "a causal relationship between number of nevi and breast disease unlikely." However, researchers believe that same genetic factors may contribute to the development of both breast cancer and moles.


Condition of the hormonal system and its impact on the appearance of moles and breast cancer were also studied by the team of scientists from Indiana University and Harvard University (Indiana University and Harvard University). They analyzed statistical data collected by the workers of the Association of nurses in USA for 24 years.


The researchers found that women with 15 or more moles on 35% more likely to have been diagnosed with breast cancer than having no mole at all. Thus, they calculated that the risk of developing breast cancer in women with 15 or more moles were 11.4%, while women with no nevi, the figure stopped by 8.48%.


Although both studies found a link between breast cancer and number of moles, to clearly explain the mechanism that leads to this respect, no team of scientists could not. However, research can be useful for identifying risk groups for breast cancer.


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