Found a new target for chemotherapy deep inside cancer cells

In the July issue of the journal Cancer Cell, Australian researchers reported that blocking a fundamental process that takes place deep inside the cancer cells, can selectively destroy them without affecting healthy cells.
For a hundred years the doctors know that abnormalities in the cell nucleolus - small spherical blob in the center of the cell nucleus - can be diagnosed as cancer. The nucleolus is composed of pieces of chromosomes, which are read for the synthesis of certain genes Ribosomal RNA (rRNA) - cellular machinery producing proteins. And now managed to get the real evidence that accelerated reading of ribosomal genes leads to abnormal nucleoli and is necessary for the survival of cancer cells. Also, investigators have shown that blockage reading accelerated mice can cause events that result in leukemia and lymphoma cell death without affecting healthy.

Thus, it was demonstrated that cancer cells are much more dependent on their ability to synthesize the ribosome than normal cells. According to the head of research Ross Hannah from the Australian Cancer Center Peter MacCallum, it is particularly important that the possibility of selective inhibition of the enzyme RNA polymerase I, responsible for the synthesis of the major ribosomal components can be used to selectively kill cancer cells while leaving healthy tissue intact. Previously it was assumed that the ability to produce ribosomes - equally important property of both cancerous and healthy cells.

Scientists make the following conclusion: selective inhibitors of RNA polymerase I can be highly effective chemotherapeutic agents. The study used the ongoing clinical trials agent CX-5461, manufactured by Cylene Pharmaceuticals.


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