Methylene blue will help to overcome a rare genetic disease Bashny.Net

A group of scientists from the University of Maryland (University of Maryland) found that a safe and inexpensive chemical — methylene blue — can be effective not only for the treatment of progeria (premature aging), but also to resist external manifestations of physiologic aging.





 

Progeria is a rare genetic disease that mimic the aging process at an accelerated pace. Symptoms usually occur within the first year of life: marked atrophic changes of the skin, subcutaneous tissue (skin thins, becomes thin, dry, wrinkled), bones and joints become brittle, muscles weak, there are degenerative processes in the teeth, hair and nails, with the progression of the disease occurs multiple organ failure, which most patients are able to live even before reaching adulthood.

Done specialists work reports that the widespread and non-toxic chemical called methylene blue can be used to treat progeria, and perhaps even to eliminate the external manifestations of aging. Research shows that small doses of methylene blue allow to almost completely restore the defects in cells suffering from progeria and eliminate age-related changes in healthy cells.

Methylene blue is an inexpensive, safe, water-soluble substance. Basically, it is used as an antiseptic and antifungal agent.

 





 

Senior author Canh Cao (Cao Kan) said that, diligently studying the effects of methylene blue on all known symptoms of progeria within the cell, scientists were able to determine that the chemical is able to restore every damaged cell structure.

 

"When we observed the treated cells, it was difficult to believe that they were once struck by progeria", – Kan Tsao.

 

Progeria is the result of a defect in a single gene responsible for the production of the protein Lamin a, which is part of the membrane of cell nuclei. If you violate the synthesis of Lamin A changes normal cell division, which leads to their rapid demise. The body stops growing and loses the ability to replace dying cells with new, which leads to accelerated aging.

 





 

In progeria most of the mitochondria of the affected cells swell and become fragmented, losing - and losing the ability to function properly. A group of researchers found that themethylene blue completely eliminates damage to the nucleus and mitochondria. The exact mechanism is still unclear, but the processed data from the chemical a "sick" cells are indistinguishable from healthy. When testing substances on healthy cells also revealed the disappearance of some of the symptoms of cellular aging.

 

“It's an exciting result, with great potential in the treatment of progeria and anti-aging,” the Zheng-Mei Xiong (Zheng-Mei Xiong).

 

Experts noted that by repeating the experiments many times, they did not notice any mistakes. Currently, they are preparing to test methylene blue in animals. published

 

P. S. And remember, only by changing their consumption — together we change the world! ©

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Source: hi-news.ru/research-development/metilenovyj-sinij-pomozhet-poborot-redkoe-geneticheskoe-zabolevanie.html