Researchers at Georgia Institute of Technology, Emory University, doctors from Atlanta and the University of Arizona have created a new class of synthetic particles that increase the natural blood clotting for the emergency treatment of traumatic injuries.
Unique scientific development will allow to solve problems of certain blood clotting disorders without the need for transfusions of natural platelets. The technology – a soft, deformable hydrogel materials. The process of clotting is called by the same factor that initiates its own processes of blood coagulation.
The bloodstream contains proteins fibrinogen, which are precursors of fibrin, the polymer that provides the basic structure for natural blood clots. They are getting the right signals from thrombin. Synthetic particles use the same trigger and are only activated when starts the natural process of clotting in the body.
The effectiveness of new particles have been tested in animal models and in a microfluidic chamber designed to simulate conditions in the circulatory system of the body. Also, scientists tested the new drug on the infant's blood. Children undergoing open-heart surgery, require their blood was diluted, reducing its clotting ability. When new gel particles were added to the diluted blood of newborns, they form clots. In addition, it was tested on blood from patients with hemophilia.
Although initially particles were developed for use on the battlefield for wounded soldiers, researchers believe that they can reduce the need for platelet transfusions in patients undergoing chemotherapy or bypass surgery. Dr. Wilbur Lam (Wilbur Lam) said: "These particles can eliminate the need for transfusion. Although they do not have all of the assets of natural platelets, experiments have shown that they help in clotting". Scientists say that artificial materials lack many features of natural platelets, but they have one thing in common. Clots formed by natural platelets, reduced for one hour, beginning the process of recovery. Clots formed from the synthetic particles are compressed for a longer period of time.
Particles will have to undergo human trials and receive permission to apply the treatment. What ultimately happens to the hydrogel particles circulating in the bloodstream will be the topic of future research, said the doctors. Particles of this size and composition, as a rule, removed from the body.
Previously, other researchers have created artificial platelets effective nanoparticles.