Scientists presented siteactivity drug against diabetes

Doctors at Imperial College (London) and LMU (Munich) have created a drug for the treatment of type 2 diabetes, which is 'switched on' by light, which is to increase the effectiveness of treatment and reduce side effects.

To create better medicines, the researchers adapted an existing type of drug of the sulfonylurea so that it changed shape when exposed to blue light. The drug would be inactive under normal conditions, and will work when the patient has light skin with a blue led.

A small amount of light will penetrate the skin, changing the form of the drug and including. This change is reversible as the drug "turns off" when the light goes out. Researchers demonstrated how a prototype drug JB253, stimulates the release of insulin from pancreatic cells in the laboratory under exposure to blue light.



Experiments led by Dr. David Hodson: "In principle, this type of therapy may better control blood sugar levels because it can be turned on for a short time when required after a meal.

We made a molecule that has the desired effect on human pancreatic cells in the laboratory. Long way to go before a therapy is available to patients, but this remains our ultimate goal."