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We have a gene resistance of gravity, without which all living things would be flat
Or even did not exist 100 years ago byEschё biologist and mathematician D'Arcy Thompson suggested that the shape of the body of animals due to the force of gravity. He also predicted that if the force of gravity on Earth was twice more, then people will not be able to walk on two legs, and most of the animals would be like short-legged lizards.
An international research team led by Dr. Makoto Furutani-Seiki University of regenerative medicine in Japan now identified a gene that helps the body to resist the action of gravity, and showed what would happen if his work will be broken.
In a study published in the journal Nature, they showed that the gene YAP damage from medaka fish, its tissues are distorted in the direction of gravity, as well as losing the proportions, resulting in her developing a flat, almost two-dimensional body. They found that the destruction of YAP gene in human cells also stop the formation of cell clusters 3D.
Scientists have shown that YAP is the main regulator of the molecular mechanisms that generate forces within and between cells, allowing the cells to take complex shapes and 3D-create complex organs such as the eyes.
The human eye contains a lens and dome structures. To view requires that all parts of the eye have unique three-dimensional shape and are precisely aligned along a longitudinal axis of body. The existence of a mechanism linking the 3D shapes of tissues and their mutual alignment, scientists had not even suspected.
This discovery is of great importance for bioengineers growers fabrics and complex organs for transplantation. Researchers have also shown that the same mechanism underlies the correct mutual alignment of tissues in the developing embryo.
One of the co-authors, Dr. Stefan Begbie, said: "At the moment, we can grow 3D clusters of cells in the laboratory, but can not reproduce the exact structure of different tissues needed for the cultivation of such complex organs such as the eyes or the heart. On the basis of the detected roles gene YAP, we hope to influence the cultivated tissue to create complex organs for further transplantation ».
via gearmix.ru/archives/18971
An international research team led by Dr. Makoto Furutani-Seiki University of regenerative medicine in Japan now identified a gene that helps the body to resist the action of gravity, and showed what would happen if his work will be broken.
In a study published in the journal Nature, they showed that the gene YAP damage from medaka fish, its tissues are distorted in the direction of gravity, as well as losing the proportions, resulting in her developing a flat, almost two-dimensional body. They found that the destruction of YAP gene in human cells also stop the formation of cell clusters 3D.
Scientists have shown that YAP is the main regulator of the molecular mechanisms that generate forces within and between cells, allowing the cells to take complex shapes and 3D-create complex organs such as the eyes.
The human eye contains a lens and dome structures. To view requires that all parts of the eye have unique three-dimensional shape and are precisely aligned along a longitudinal axis of body. The existence of a mechanism linking the 3D shapes of tissues and their mutual alignment, scientists had not even suspected.
This discovery is of great importance for bioengineers growers fabrics and complex organs for transplantation. Researchers have also shown that the same mechanism underlies the correct mutual alignment of tissues in the developing embryo.
One of the co-authors, Dr. Stefan Begbie, said: "At the moment, we can grow 3D clusters of cells in the laboratory, but can not reproduce the exact structure of different tissues needed for the cultivation of such complex organs such as the eyes or the heart. On the basis of the detected roles gene YAP, we hope to influence the cultivated tissue to create complex organs for further transplantation ».
via gearmix.ru/archives/18971
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