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Israeli scientists have invented a cure for obesity
Researchers claim to have found a genetic switch that drives our metabolism. They identified a protein that controls metabolism — and used it to significantly reduce the development of obesity and diabetes in mice. By manipulating a biochemical process based on the ability of cells to burn energy, researchers can develop new methods for weight loss, which will be a major breakthrough in the fight against obesity. Researchers from Israel’s Beth Deaconess Medical Center (BIDMC) published their research April 10 in the journal Nature.
Their results show that reducing the amount of nicotinamide N-methyltransferase (NNMT) protein in fat and liver significantly reduced the development of obesity and diabetes in mice. This is due to a biochemical mechanism known as a “useless cycle,” in which cellular reactions are accelerated, thereby consuming more energy. “With this discovery, we have metabolic manipulation tools that can help increase the rate of energy intake and lead to weight loss,” says lead author Dr. Barbara Kahn. “A useless cycle is one way to speed up energy utilization in cells. The technology we used to suppress the NNMT gene is already being used to treat other diseases in humans.”
When comparing fat from mice that had been exposed to diabetes with fat from healthy mice, the researchers found that animals that were prone to developing diabetes had a lot of NNMT in fat and liver. Importantly, the team used oligonucleotide administration (ASO) technology to neutralize the NNMT gene. The substance is already approved by the U.S. Food and Drug Administration (FDA) as a treatment for the genetic causes of high cholesterol or hyperlipidemia, as well as in the treatment of viral eye infection. For this reason, researchers hope to easily pass clinical trials and in the very near future to present humanity with a cure for obesity.
Source: brainswork.ru
Their results show that reducing the amount of nicotinamide N-methyltransferase (NNMT) protein in fat and liver significantly reduced the development of obesity and diabetes in mice. This is due to a biochemical mechanism known as a “useless cycle,” in which cellular reactions are accelerated, thereby consuming more energy. “With this discovery, we have metabolic manipulation tools that can help increase the rate of energy intake and lead to weight loss,” says lead author Dr. Barbara Kahn. “A useless cycle is one way to speed up energy utilization in cells. The technology we used to suppress the NNMT gene is already being used to treat other diseases in humans.”
When comparing fat from mice that had been exposed to diabetes with fat from healthy mice, the researchers found that animals that were prone to developing diabetes had a lot of NNMT in fat and liver. Importantly, the team used oligonucleotide administration (ASO) technology to neutralize the NNMT gene. The substance is already approved by the U.S. Food and Drug Administration (FDA) as a treatment for the genetic causes of high cholesterol or hyperlipidemia, as well as in the treatment of viral eye infection. For this reason, researchers hope to easily pass clinical trials and in the very near future to present humanity with a cure for obesity.
Source: brainswork.ru
