Scientists of Japan and the United States announced the start of clinical trials of a new drug against aging

Medical scientists at Washington University, St. Louis, USA, and Keio University, Japan, conducted the final preparations for the start of large-scale clinical trials of a new drug, the main purpose of which - a significant extension of human life. According to preliminary plans, the project managers start test is scheduled for early to mid-July, at the same time, in accordance with the laws of Japan, the "green light" for them to give the Committee on Research Ethics (Research Ethics Committee) Keio University.

At the stage of clinical trials will be assessed the effectiveness of the drug and its safety for the human body. Research based on the latest drug substance nicotinamide mononucleotide (nicotinamide mononucleotide, NMN) have already been tested in animals and showed significant positive changes in the dynamics of the aging process. It is reported that during the testing of this drug will be administered to adults and ten healthy people, volunteers.

During the experiments already conducted research team led by an expert on gerontology professor Shinichiro Imai of Washington University was able to show that NMN substance activates the genes responsible for the production of sirtuin protein, known for its anti-aging effect on the body and called the "elixir of youth." As demonstrated by a series of experiments with laboratory mice, conducted by the team of Prof. Imai earlier, protein sirtuins really demonstrates the ability to postpone age-related changes, manifested in lowering metabolism and vision. And not only ...

Results of the experiment with laboratory mice, more

During their experiments, the researchers examined mice, "programmed to manufacture" Sirtuin, while in some of the mice was so overproduction throughout the body, while the other - only in certain tissues. Here, scientists have come to a curious conclusion: as it turned out, to increase the life expectancy is crucial that sirtuins was active specifically in the area of ​​the brain. Interestingly, the increase in lifetime in this case was exactly as in conventional mice podsazhennyh to low-calorie diet. But if the sirtuin levels in the brain increased, the mice could eat whatever and whenever: their lifetime is still extended

. Further studies have shown that the extension of life was accompanied by a set of physiological and behavioral characteristics: the mice were more active at night (ie when it befits to be active), they increased body temperature and the amount of consumable oxygen, improved muscle tone, and the day they fell asleep faster and sleep tight. Finally, these changes, as well as the significant increase in life span were observed in males and females. According to Mr. Imai and his colleagues, the longevity of females increased by 16% in males - by 9%. If you relate to the duration of human life, then, accordingly, a woman with such changes in the body may well live to a hundred years, and the average "minimum" for men, without much stress and diet, to reach eighty.

The researchers also noted that in mice with a high content of sirtuin in the brain was also above the threshold of resistance to cancer. As for the key issue - aging, it is very important to note that the shift was recorded since the start of the aging process, but do not stretch over time his rhythm. Simply put, aging itself is not slowed down, but it began much later. Subsequently, in this regard, sirtuins dubbed

«fountain of youth." The findings - only part of the extensive research already for completed Imai and his group. The researchers went further and tried to determine which region of the mouse brain reacts to sirtuins most active, pushing the aging process. As a result of the search, it was found that such sites are the dorsolateral and the lateral nucleus of the hypothalamus (part of the brain, is deeply involved in the regulation of metabolism. The lateral nucleus of the hypothalamus, as we know, are regulators of feeding behavior. As it turned out, sirtuins increases neuronal sensitivity to orexin, neuropeptide hormones, affecting, in turn, the metabolism and are involved in the regulation of the sleep cycle.

At the same time, according to scientists, the joint action of sirtuin and orexin has caused intense stimulation signals to the hypothalamus sends muscles. These signals stimulate physiological rebuilding muscle tissue that alters its metabolism and slows the aging process, which is manifested primarily in the muscles.

Of course, the fact of slowing aging in the course of the experiments was observed not only in the muscles, but also for all the physiological pattern. Thus, the group Imai has provided very strong arguments in favor of that protein sirtuins and aging process is linked in the most direct way. And today, you now need to find out whether a similar effect is observed in the human.



The results of the first phase of clinical trials will allow scientists to answer the question of whether the substance is safe for human NMN. In the absence of any side effects, the researchers will be able to proceed to the main purpose of the experiments: an assessment of whether the drug is destined to play a role for the mankind long-awaited "elixir of youth."

The-japan-news.com

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