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Genes awakening after death
Some genes, "sleeps" for life immediately after the appearance of the body to light, suddenly again are active immediately after his death, and show it in the body, shows no external signs of life for a few days.
From the point of view of rational thought and science of all of the above may seem strange and even unnatural, but as shown recent research, many genes actually work in the body even after his move to a state that is associated in our minds with death. Experts in forensic science, exploring the liver or the blood of the dead, for a long time know about the similarity of this posthumous activity. Now researchers from the University of Washington and colleagues from the University of Alabama and the Max Planck Society have set ourselves the ambitious task counted on the possibility of all the genes work "posthumously", as well as find out how long they continue to be active. The research results were published in Science on June 22, 2016.
Genetic activity was measured in the bodies of mice and fish Danio rerio, and the result showed that the gene continuing to do the work after the death at their level a lot is sufficient, or rather, more than 1000. Initially, scientists have suggested that the cessation of the activity of genes can be fixed already a few hours later, but the results of the experiment showed something else: hundreds of genes continued to develop its program and a few days after death. For mice this interval was two days, and fish - four. At the same time, which is amazing, "otherworldly" genetic activity can not be described smoothly descending curve or a straight line, some genes in the first days showed increased activity, then, having a point of maximum, started "to lose acceleration" and eventually "fell asleep" until its complete stop. Most likely, this dynamic was made possible thanks to the residual energy and other resources that cell to its full biological death could still be used for the synthesis of RNA.
Which genes are the same in this case? First of all they were genes that inhibit the biochemical, physiological and molecular stress and stimulate the immune system to carry out attempts to cope with the problem. But if such a result is quite consistent with the assumptions of the researchers, the other set of genes from the number of "over-active" I was completely unpredictable. The preprint articles in the pages of the authors of bioRxiv claim that after death, as shown by their research, with a purpose activated genes for embryonic development. To explain the observed fact scientists can not only damage the assumption that after the death of a number of parameters is similar to the cell becomes the embryo cell. and the other oddity was discovered, completely beyond the scope of existing scientific logic: the death of activated oncogenes that promote the development of malignant tumors. Here researchers conducted an obvious parallel between the tendency of occurrence of cancer in patients who have been transplanted body of a recently deceased person associated with a predisposition increasing activity awakened alien oncogenes.
If similar manifestations of genetic activity with similar genes will be observed after a person's death, the results can be very useful for molecular biologists, transplant and medical forensics, which in view of new data on the post-mortem genetic activity could specify the exact time death.
what is the probable reason for this has not yet studied the phenomenon? B>
What makes genes remain silent all his life, more active, even for a short time, the field of death? Perhaps the explanation lies in the fact that in the dying body naturally breaks down the genetic network setup: the system of molecular cell prohibitions and permits, which made some genes work, and others - to remain silent, simply ceased to fulfill the instructions
. To support the work of all these complicated machines gene "schedule", is required to expend energy, but after the death of not renewable energy, and other resources is rapidly melting, so that some of the genes are given the opportunity finally to "show" themselves.
Science
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Source: geektimes.ru/company/dronk/blog/277804/
From the point of view of rational thought and science of all of the above may seem strange and even unnatural, but as shown recent research, many genes actually work in the body even after his move to a state that is associated in our minds with death. Experts in forensic science, exploring the liver or the blood of the dead, for a long time know about the similarity of this posthumous activity. Now researchers from the University of Washington and colleagues from the University of Alabama and the Max Planck Society have set ourselves the ambitious task counted on the possibility of all the genes work "posthumously", as well as find out how long they continue to be active. The research results were published in Science on June 22, 2016.
Genetic activity was measured in the bodies of mice and fish Danio rerio, and the result showed that the gene continuing to do the work after the death at their level a lot is sufficient, or rather, more than 1000. Initially, scientists have suggested that the cessation of the activity of genes can be fixed already a few hours later, but the results of the experiment showed something else: hundreds of genes continued to develop its program and a few days after death. For mice this interval was two days, and fish - four. At the same time, which is amazing, "otherworldly" genetic activity can not be described smoothly descending curve or a straight line, some genes in the first days showed increased activity, then, having a point of maximum, started "to lose acceleration" and eventually "fell asleep" until its complete stop. Most likely, this dynamic was made possible thanks to the residual energy and other resources that cell to its full biological death could still be used for the synthesis of RNA.
Which genes are the same in this case? First of all they were genes that inhibit the biochemical, physiological and molecular stress and stimulate the immune system to carry out attempts to cope with the problem. But if such a result is quite consistent with the assumptions of the researchers, the other set of genes from the number of "over-active" I was completely unpredictable. The preprint articles in the pages of the authors of bioRxiv claim that after death, as shown by their research, with a purpose activated genes for embryonic development. To explain the observed fact scientists can not only damage the assumption that after the death of a number of parameters is similar to the cell becomes the embryo cell. and the other oddity was discovered, completely beyond the scope of existing scientific logic: the death of activated oncogenes that promote the development of malignant tumors. Here researchers conducted an obvious parallel between the tendency of occurrence of cancer in patients who have been transplanted body of a recently deceased person associated with a predisposition increasing activity awakened alien oncogenes.
If similar manifestations of genetic activity with similar genes will be observed after a person's death, the results can be very useful for molecular biologists, transplant and medical forensics, which in view of new data on the post-mortem genetic activity could specify the exact time death.
what is the probable reason for this has not yet studied the phenomenon? B>
What makes genes remain silent all his life, more active, even for a short time, the field of death? Perhaps the explanation lies in the fact that in the dying body naturally breaks down the genetic network setup: the system of molecular cell prohibitions and permits, which made some genes work, and others - to remain silent, simply ceased to fulfill the instructions
. To support the work of all these complicated machines gene "schedule", is required to expend energy, but after the death of not renewable energy, and other resources is rapidly melting, so that some of the genes are given the opportunity finally to "show" themselves.
Science
That's all, you had Dronk.Ru. Do not forget to return the money for purchases in China and to subscribe to our blog, will be much more interesting
Recommended:. B>
- Save up to 8% with each purchase on AliExpress and other online stores
China - Why do online shops give the money for the purchase
? - Return the money - Choosing a cashback service to Aliexpress
- History of Dronk.ru - the choice quadrocopters to return the money for buying on AliExpress, and not only
- The best cashback service or 5 main evaluation criteria cashback service
Source: geektimes.ru/company/dronk/blog/277804/
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