Chitosan can be used for treating cancer

Scientists from the Center "Bioengineering" RAS filled nanoparticles based on related living organism polysaccharide chitosan antibiotic doxorubicin, which is used in cancer chemotherapy. It is possible to reduce the negative effects of the drug while maintaining its anticarcinogenic activity.

It is known that nanosized drug delivery systems are able to overcome the various biological barriers (including cellular and nuclear membrane), delivered to the targeted cells infected organs and generally stay in the body longer. But to work with solutions of anticancer drugs in its pure form is not always possible - many drugs have a number of serious shortcomings. For example, doxorubicin (DOKS) is rapidly degraded in the bloodstream, plus cardio and nephrotoxic.

Nanoparticles filled doxorubicin produced by the following procedure: chitosan attached to succinic acid residues, and then of such a modified chitosan nanoparticles obtained suspension. And already formed nanoparticles planted antibiotic molecule. It was found that 1 mg of nanoparticles can attach up to 170 mg of doxorubicin.

To see how destroyed nanoparticles loaded with antibiotic inside the cell, they are labeled with fluorescein.

Nanoparticles of chitosan-modified doxorubicin can effectively bind and deliver an antibiotic, not only in the cell itself, but also in its core. Thus anticarcinogenic activity of antibiotic adsorbed nanoparticles is not reduced. All this allows, firstly, increase the circulation time of the antibiotic in the blood, which has a positive effect on the efficiency of delivery to the cells and, consequently, the therapeutic effekte.Vo Second, it helps to reduce its toxicity in the living body.

Source: www.nanonewsnet.ru

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